Sabino Vesce, PhD

Nacionalidade: Italian

Formação Académica:
PhD, Dept. of Pharmacology & Neurosciences, University of Dundee, UK

Cargos Actuais: First assistant, Dept. of Cellular Biology and Morphology, Faculty of Biology & Medicine, University of Lausanne; Teaching duty: Laboratory of Anatomy; Main research topic: Astrocytic dysfunction in the pathogenesis of Alzheimer’s disease.

Trabalhos relacionados com a palestra:
-Vesce S, Rossi D, Brambilla L, Volterra A. Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation. International Reviews in Neurobiology, 82 (2007): 57-71.
-Vesce S, Jekabsons MB, Johnson-Cadwell LI, Nicholls DG. Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons. Journal of Biological Chemistry, 280(2005): 38720-38728.
-Vesce S, Kirk L, Nicholls DG. Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate. Journal of Neurochemistry, 90 (2004): 683-693.

Resumo da Palestra
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive loss of cognitive function. Biochemical hallmarks of AD are the formation of neurofibrillary tangles and amyloid-b (Ab) deposits that are accompanied by marked neuronal loss in the neocortex and hippocampus. Chronic inflammatory reaction involving glial cells (astrocytes and microglia) is well documented around Ab plaques, but it is unclear whether this event plays a causative role in AD. In the past few years, technical advancements in the field of fluorescence imaging have provided the opportunity to study glial and neuronal function in the brain of living mice. In the context of AD, such advancements translated into the discovery of important roles played by glial cells that may be relevant to the disease pathogenesis.